Turmeric and Curcumin
Turmeric comes from the root of the Curcuma longa plant 薑黃植物, a member of the ginger family and native to tropical areas of Asia. Its rhizomes (rootstocks) are dried and ground into an orange-yellow powder to be used as a spice, food coloring, or dye. The orange-yellow powder is best known giving curry powder its yellow glow.
- A Potent, Yet Safe Anti-Inflammatory
- An Effective Treatment for Inflammatory Bowel Disease
- Cardiovascular Protection
- Help for Cystic Fibrosis Sufferers
- Improve Liver Function
- Inhibits Cancer Cell Growth and Metastases
- Protection against Alzheimer’s Disease
- Reduce Risk of Childhood Leukemia
- Relief for Rheumatoid Arthritis
- Turmeric and Onions May Help Prevent Colon Cancer
Various risk factors have been associated with Colorectal cancer (CRC 大腸癌) including increasing age and diet. Epidemiological 流行病學 and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat diets can promote obesity resulting in;
- Insulin resistance
- Development of oxidative stress
- Increased cell proliferation
- Suppression of apoptosis.
Curcumin (Curcuma longa), the main yellow pigment in turmeric, was selected to test because of its reported anti-tumor activity. APC Min mice, which develop intestinal polyps having many molecular features of CRC, were fed a diet containing 35% pork fat, 33% sucrose, and a protein and vitamin mineral mixture (HFD-High Fat Diet) with or without 0.5% curcumin. These cohorts were compared to APC Min mice receiving standard rodent chow (RC 囓齒類動物食物) with 8% fat. APC Min mice fed the HFD for 3 months had a 23% increase in total number of polyps compared to APC Min mice on RC. Curcumin was able to significantly reverse the accelerated polyp development associated with the HFD suggesting it may be effective clinically in helping prevent colon cancer even when ingesting high amounts of fatty foods. The anti-tumor effect of curcumin was shown to be associated with enhanced apoptosis 細胞凋亡 and increased efficiency of DNA repair. Since curcumin prevented the gain in body weight seen in APC Min mice ingesting the HFD, modulation of energy metabolism may also be a factor.